PSTPIP2 and chronic recurrent multifocal osteomyelitis: Utilizing murine models of CRMO, including the proline-serine-threonine phosphatase interacting protein 2 (PSTPIP2) deficient and Ali18 models, it has been shown that the disease is a hematopoietically-driven innate immune system disorder, occurring independent of the adaptive immune system [37,38,55,56].