IL1B and Majeed syndrome: As expected, monocytes and monocyte-derived M1-like macrophages from patients with Majeed syndrome as well as monocytes from individuals with another genetically driven NLRP3 inflammasomopathy Neonatal Onset Multisystem Inflammatory Disorder [NOMID] had elevated caspase-1 activity and their cells secreted more IL-1β levels when compared to healthy controls [81].