In fact, 70% of CLL/SLL and 57% HGBL-DH (19/27 and 4/7, respectively) displayed BCL2-dependency, versus only 21% (19/90) for all other NHLs (p < 0.0001 and p = 0.0310, respectively, response defined as ≥30% cytochrome c release). This evidence concerns the gene CYCS and B-cell chronic lymphocytic leukemia.