CYP2E1 belongs to the cytochrome P450 family; it is involved in fatty acid oxidation [104] and is associated with NAFLD progression since it possesses an extremely high NADPH oxidase activity that leads to the production of ROS (H2O2, hydroxyl radical, and superoxide anion) [105]. Here, CYP2E1 is linked to metabolic dysfunction-associated steatotic liver disease.