For example, propranolol, a non-selective adrenergic blocker, can cause cell cycle arrest and induce apoptosis in gastric carcinoma cells by blocking nuclear factor-kB (NF-kB), MMP2/9, VEGF, and cyclooxygenase-2 (COX-2) [30,31]. This evidence concerns the gene NFKB1 and gastric carcinoma.