IL1B and neuropathic pain: Therefore, in this study, we screened, for the first time, clinically approved drugs from a large-scale chemical library to identify those that have an inhibitory effect on P2X7R activation and identified cilnidipine, a Ca2+ channel blocker that inhibits P2X7R, microglial IL-1β release, and behavioral hypersensitivity in a rat model of neuropathic pain.