TGFB1 and renal fibrosis: Other studies evaluating the functional role of renal TGF-β signalling yielded interesting findings demonstrating that treatment in vivo of STZ-induced diabetic mice with neutralizing monoclonal antibodies against all three TGF-β isoforms reduced the expression of mesenchymal markers such as collagen and fibronectin, ameliorating renal fibrosis [180,181,182].