In RA, TGF-β1 performs actions that range from a pro-angiogenic role in the synovial membrane (SM) [137] to the induction and synthesis of pro-inflammatory cytokines [138], MMPs [139], and various agents responsible for fibrinolysis and tissue remodelling, such as aggrecanase [140] and urokinase-type plasminogen activator [141]. Here, TGFB1 is linked to rheumatoid arthritis.