MC4R and obesity due to melanocortin 4 receptor deficiency: For instance Alpha-Ketoglutarate Dependent Dioxygenase (FTO), Insulin Like Growth Factor 2 MRNA Binding Protein 2 (IGF2BP2), Brain Derived Neurotrophic Factor (BDNF), Melanocortin 4 Receptor (MC4R), and Apolipoprotein (APO-A) gene family, among others, have been shown to present SNPs associated with those disorders [23,24,25,26,27,28,29] The genetic susceptibility to obesity is also influenced by an obesogenic environment for its phenotypic expression (nutrigenetics) (Figure 1).