GART and breast neoplasm: Among these cell fitness molecules, we observed a widespread mRNA overexpression and copy number amplification of Geranylgeranyl pyrophosphate synthase (GGPS1), Farnesyl diphosphate synthase (FDPS), and GART (also known as glycinamide ribonucleotide formyl transferase—(GARFT) in breast tumors (Figure 4A and Supplementary Figure S6).