We also observed that the overexpression of HMGCS1, GGPS1, FDPS, and GART in breast (Figure 4), ovarian, endometrial, pancreatic, and CNS cancers (Supplementary Figure S10) correlated well with a reduction in the overall survival of patients when compared with that of patients without overexpression of these genes. Here, HMGCS1 is linked to central nervous system cancer.