Apart from disrupting the role of Fascin1 in tumor-cell invasion and metastasis via inhibiting actin-based membrane protrusions, RAL could also abrogate cancer metastatic colonization by blocking metabolic stress resistance and mitochondrial oxidative phosphorylation (OXPHOS), as Fascin1 has shown to be involved also in stabilizing mitochondrial actin filaments under metabolic stress, at least in lung cancer [43]. This evidence concerns the gene RALA and lung carcinoma.