At a multiple regression analysis, the 25(OH)D concentration was the only significant predictor of CRP and depression, so that for each 1.0 nmol/L decrease in serum levels of 25(OH)D, there was an increase by 0.041 mg/L in serum levels of CRP and an increase by 0.063 points in depression score [133]. Here, CRP is linked to depressive disorder.