In RVFV NSs coding region mutants, virulence is decreased and infection can be characterized by lack of filament formation in nuclei of infected cells [83], decreased IFN antagonism and inability to degrade PKR [84], reduced general transcription inhibition and cytotoxicity [80], and reduced ability to inhibit antiviral signaling by macrophages [85]. Here, EIF2AK2 is linked to infection.