Filamin A binds to and promotes activation of RhoA [39]; therefore, filamin A and Gαq/11 downregulation occurring in parathyroid tumors may inhibit RhoA activation and the inhibitory effect of the Hippo signaling pathway on YAP1 [40], contributing to reduction in YAP1 nuclear accumulation. This evidence concerns the gene FLNA and tumor of parathyroid gland.