Transcriptomic analysis of ARVC hearts provided robust evidence of dysregulation of several genes associated with Rho-signaling [34], while more recently it was demonstrated that an impaired RhoA-ROCK signaling, through the RhoA/MRTF/SRF circuit, plays a crucial role in the switch of cardiomyocytes to adipocytes [31]. The gene discussed is RHOA; the disease is arrhythmogenic right ventricular cardiomyopathy.