Based on current literature, the devised in silico model of ARVC allowed us to draw some important conclusions: (i) simultaneous activation of RhoA-ROCK and canonical Wnt pathways leads to the most effective inhibition of PPARγ expression, the master regulator of adipogenesis; (ii) stability of desmosomes is crucial for the regulation of adipogenesis; and (iii) the overexpression of Wnt5b alone is not sufficient to induce an adipocytic phenotype. This evidence concerns the gene WNT5B and arrhythmogenic right ventricular cardiomyopathy.