Using an iPSC-based strategy, the activity of RhoA-ROCK pathway was recently linked to the maintenance of an activated MRTF/SRF (Myocardin-Related Transcriptional Factors/Serum Response Factor) transcriptional program, which is responsible for the regulation of cardiomyocytes identity in a human model of ARVC [31]. Here, RHOA is linked to arrhythmogenic right ventricular cardiomyopathy.