This study is in partial agreement with our in silico analysis, in which overexpression of SPDL1 mRNA was independently associated with a poor OS of PAC patients (adjusted HR = 2.40, 95% CI 1.53–3.75; p < 0.0001); however, it was not significantly correlated with any of the established clinicopathological features (p > 0.05), albeit there was a trend towards its higher prevalence of in pT3–pT4 tumors than pT2 and pT3 tumors (p = 0.11). Here, SPDL1 is linked to gonorrhea.