In contrast, Ad.5-CTV and Ad.5-TCTV significantly inhibited tumor growth on both flanks, highlighting the significant “bystander” anti-tumor function of mda-7/IL-24 as well as possible virus and/or mda-7/IL-24 transfer from the infected to the non-infected tumor site (which was anticipated based on the compromised immune system in these nude mice) (Figure 5). The gene discussed is IL24; the disease is neoplasm.