MDA-7/IL-24 selectively induces apoptosis and/or toxic autophagy in a broad spectrum of cancer cell types, including breast cancer [27,29,30,31,32,33,34], prostate cancer [25,35,36,37,38], melanoma [31,34,39,40,41,42,43,44,45], glioblastoma multiforme [22,24,46,47,48,49], neuroblastoma [50], lung [14,21,23,26,28], and numerous other cancers [7,8,13,15,17]. The gene discussed is IL24; the disease is melanoma.