MDA-7/IL-24 promotes cancer-selective apoptosis by inducing endoplasmic reticulum (ER) stress, which causes up-regulation of BiP/GRP78, induction of pro-apoptotic proteins (such as BAX), and repression of anti-apoptotic proteins (such as BCL-2) [51,52,53,54]. This evidence concerns the gene BCL2 and cancer.