We previously engineered a conditionally replication-competent bipartite type 5 adenovirus, in which the cancer-selective truncated PEG-3 promoter controlled the viral replication and the cytomegalovirus (CMV) promoter regulated the mda-7/IL-24 gene expression (Ad.5-PEG-E1A-CMV-MDA-7), a cancer terminator virus (CTV) [44,58,59,60]. This evidence concerns the gene DHTKD1 and cancer.