In contrast, it does not promote similar changes in normal cells and has not shown toxicity in pre-clinical animal models of cancer [7,8,13,15,17] or in patients with advanced cancers that received direct intratumoral injection with an mda-7/IL-24 expressing replication incompetent type 5 adenovirus in a Phase I clinical trial [15,17,18,19,20]. The gene discussed is IL24; the disease is cancer.