We also defined the essential antiapoptotic role of NF-κB as a mechanistic link in supporting its tumorigenic effect in vitro and in vivo [13,14,15,16,17,18,19] and that hypopharyngeal cancers harvested from patients with documented biliary esophageal reflux exclusively demonstrated highly activated NF-κB and characteristic mRNA and miRNA phenotypes vs. controls similar to those described in our laboratory models [20]. This evidence concerns the gene NFKB1 and hypopharynx cancer.