We demonstrate that weakly acidic bile is very capable of promoting transcriptional activation of NF-κB associated genes participating in oncogenic pathways in HNSCC, including inflammatory molecules, such as Tnf and Il6, antiapoptotic Bcl-2, and oncogenic factors Egfr, Wnt5a, and Rela [21,22,23,24,25]. Here, TNF is linked to head and neck squamous cell carcinoma.