The key role of NF-κB in cancer initiation and progression, including head and neck squamous cell carcinomas (HNSCC), has been widely discussed and documented by its complex interactions with multiple other signaling molecules and pathways, including TNF/IKK/Bcl-2, EGFR/Ras/RAF/MAPK, IL-6/STAT3, Akt/PI3K/mTOR, and wnt/β-catenin [21,22,23,24,25]. This evidence concerns the gene TNF and cancer.