In the CNS, EVs are also indicated as potential carriers of misfolded proteins involved in neurodegenerative disorders, such as Tau and amyloid β in AD, α-synuclein in PD, TAR DNA-binding protein 43 (TDP43) and copper zinc superoxide dismutase 1 (SOD1) in ALS, suggesting their possible role as potential biomarkers for different neurodegenerative diseases [50,51]. Here, MAPT is linked to amyotrophic lateral sclerosis.