APP and Alzheimer disease: Similarly, the uptake of exosomes enriched in miRNAs released by human neuroblastoma cells (SH-SY5Y) overexpressing the APP gene with AD-linked mutations resulted in a comparable increase of miR-155, miR-146a and miR-124 in the human microglial cell line (HMC3), as well as in the upregulation of pro-inflammatory markers, including IL-10 and Arginase 1 expression [68].