Among the canonical LPS inflammatory stimulus acting on microglia, P2X7 receptor activation trough ATP stimulation has been shown to increase miRNA-125b in microglia [124] and consequently the inflammatory mediator NF-κB [125,126], which was then decreased by miRNA-125 inhibition in microglia overexpressing the human SOD1 with ALS-linked mutations [124,127]. Here, SOD1 is linked to amyotrophic lateral sclerosis.