Finally, memory ability and behavior were significantly improved in APP/PS1 double transgenic mouse model of AD through the injection of miRNA-22 mimic that also attenuated the activation of NLRP3 inflammasome and the expression of inflammatory factors in mouse hippocampus, as well as the expression of Gasdermin-D, a critical mediator of innate immune defense [70]. The gene discussed is APP; the disease is Alzheimer disease.