In this context our algorithm encompassed: (a) Physical exam and history, (b) complete blood count (number of red blood cells and platelets, number and type of white blood cells), (c) amount of hemoglobin, (d) blood chemistry studies and serum protein electrophoresis, (e) blood and urine immunoglobulin studies for free light chain quantification (i.e., for multiple myeloma, beta-2-microglobulin, M protein, free light chains), (f) twenty-four-hour urine test, and (g) immunochemistry on oral mucosa specimen to evaluate the plasma cells mono/polyclonality. Here, B2M is linked to plasma cell myeloma.