Another histone demethylase INCREASE IN BONSAI METHYLATION1 (IBM1) facilitates the transcriptional activation of defense marker genes PR1/2 and FRK1 in Arabidopsis with Pst DC3000 infection, allowing a permissive chromatin at these genes by increasing the active H3K4me3, and reducing the inactive H3K9me2 marks [133]. The gene discussed is TMEM37; the disease is infection.