GBM cells produce different ECM components such as hyaluronic acid (HA), matrix metalloproteinase-2 (MMP2), matrix metalloproteinase-9 (MMP9), integrins, tenascin-C [63], and fibronectin [64] to degrade and remodel the ECM for tumor invasion [65,66,67]. Here, MMP2 is linked to neoplasm.