GBM cells also release a number of immunosuppressive factors, including TGF-β, prostaglandin E (PGE), interleukin-1 (IL-1), interleukin-10 (IL-10), and fibrinogen-like protein 2 (FGL2) that suppress DC priming/activation of immune effector cells [101]. This evidence concerns the gene IL10 and glioblastoma.