Pseudopalisades secrete hypoxia-inducible factor (HIF-1), vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF), matrix metalloproteases (MMPs), and interleukin-8 (IL-8) that promote microvascular proliferation, angiogenesis, and tumor expansion [51]. Here, CXCL8 is linked to neoplasm.