Mesenchymal GBM is featured by focal hemizygous deletions of a chromosomal region at 17q11.2, co-mutations in neurofibromin 1 (NF1) and PTEN genes, and enrichment of tumor necrosis factor (TNF) super family pathway and nuclear factor kappa B (NF-κB) pathway genes (e.g., TNFRSF1A associated via death domain [TRADD], v-rel avian reticuloendotheliosis viral oncogene homolog B [RELB], TNF receptor superfamily member 1A [TNFRSF1A]) [81]. The gene discussed is TNFRSF1A; the disease is glioblastoma.