The common markers for classical GBM include the neural precursor and stem cell markers nestin, notch (neurogen locus notch homolog protein 3 [NOTCH3], jagged canonical notch ligand 1 [JAG1], O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase [LFNG] and sonic hedgehog (smoothened, frizzled class receptor [SMO], growth arrest-specific 1 [GAS1], GLI family zinc finger 2 [GLI2])) [81]. The gene discussed is LFNG; the disease is glioblastoma.