JUP and age-related macular degeneration: Fundus showed an expanding laser burn with inflammatory lesion-like morphology or drusen-like deposits in both Pg- and biofilm-infected AMD+PD retinae after 6 weeks compared to CNV control (Figure 3A–C; Figure S2A–E). OCT imaging found apparent drusen-like deposit in the subretinal area and obvious decrease of retinal thickness in both Pg- and biofilm-infected Li-CNV mice at 6 weeks (Figure 3E,F; Figure S2G–J,L–O).