An extensive crosstalk occurs between the mediators of oxidative stress and unfolded-protein stress; protein-kinase-like ER kinase (Perk), activating transcription factor-6 (Atf6) transducers in the regulation of VEGF expression, which is highly significant in CNV formation and eliciting AMD-related pathological changes [84,88,120,121]. The gene discussed is EIF2AK3; the disease is age-related macular degeneration.