PTEN and lung carcinoma: It has been reported that miRNA-130 can function as a tumor-promoting factor via inducing enhancer of zeste homolog 2 (EZH2) expression [181], while another study focuses on the tumor-suppressing role of miRNA-130 in lung cancer, showing that it can induce apoptosis in lung cancer cells and impair their proliferation via PTEN upregulation [182].