Indeed, ineffective HO-1 upregulation has been described in a mouse model of progressive post-ischemic inflammation [308], while a decreased Nrf2 expression (HO-1 transcription factor) was also reported in another mouse model of CKD [309,310] following upregulation of the Nrf2 repressor Keap1. The gene discussed is HMOX1; the disease is chronic kidney disease.