Infusion of Angiotensin II (Ang II) increased HO-1 mRNA levels and its expression in adventitial and endothelial cells in Ang II–induced, hypertensive rat aortas, but losartan or hydralazine treatments prevented both Ang II induction of hypertension and upregulation of HO-1 expression [262]. The gene discussed is HMOX1; the disease is Hypertension.