Interestingly, long GT tandem repeats, responsible for decreased inducibility of HO-1 expression [126], were independently associated with the occurrence of AKI in a monocentric SCA patients cohort [127], raising the possibility of a protective effect of HO-1 expression in patients; HO-1 expression is also induced in kidneys of various SCA mice models [124,128,129]. The gene discussed is HMOX1; the disease is acute kidney injury.