NOS2 and glomerulosclerosis: Among HO-1 inducers, hemin has been closely examined in co-administration with STZ and was associated with drastically increased HO-1 expression, especially in tubules, which interestingly was associated with improved renal function, decreased inducible NOS (iNOS), blood glucose levels, micro-albuminuria, glomerulosclerosis and fibrosis at 60 days [197].