Twenty-four sessions (twice a week, 12 weeks) of 75 min of training (10 min warm-up, 2 × 25 min moderate-intensity aerobic exercises at 70% VO2max and muscle strengthening, 10 min stretching) combined with a balanced diet improved the BMI, metabolic profile, and insulin resistance in 42 overweight and obese BC survivors, along with decreasing leptin (not significant) and adiponectin (significant) [245]. Here, LEP is linked to breast cancer.