In 23 stage I–III CRC patients randomized to either low- (150 min/week) or high-dose (300-min/week) 6-month aerobic activity at 50–70% of the age-predicted maximum HR, circulating tumor cells was significantly reduced, along with BMI, insulin, and soluble ICAM-1 [231]. The gene discussed is ICAM1; the disease is neoplasm.