The mRNA expression data for 71 CRC tissues have revealed that the expression of TRAIL-R2 is inversely related to LCN2 and LCN2 knockdown in CRC cells, which increases the sensitivity to TRAIL via p38 MAPK/CHOP-induced upregulation of TRAIL-R2 [138]. This evidence concerns the gene TNFSF10 and colorectal carcinoma.