IL2 and neoplasm: In another study, 20 stage IIB–IIIC BC patients underwent 20–45 min cycle ergometer sessions (55–100% VO2max, 3 times/week, 12 weeks) and experienced decreased tumor hypoxia; enhanced tumor vascularization; increased circulating endothelial progenitor cells; and decreased IL-1β, IL-2, and NF-κB signaling [230].