TP53 and glioblastoma: In GBM tumor protein 53 (TP53), ubiquitin-conjugating enzyme E2L (UBE2l), signal transducer and activator of transcription 3 (STAT3, down), epidermal growth factor receptor (EGFR), inhibitor of nuclear factor-kappa B kinase subunit beta (IKBKB, down), ras homolog family member A (RHOA, down), AKT serine/threonine kinase 1 (AKT1), small ubiquitin-like modifier 1 (SUMO1), RELA proto-oncogene, NF-kB subunit (RELA), TNF receptor-associated factor 2 (TRAF2) identified as hubs (Figure 4B).