BRCA1 and ovarian carcinoma: One of 9 mutations in BRCA1 was detected in 220 out of 2095 (10.5%) ovarian cancer cases and in 5 out of 1743 controls (0.29%), and was associated with odds ratio 40.8 (95% CI: 18.7–114.8; p = 0.29 × 10−15).