The serum levels of HOTAIR and PVT1 were significantly higher in the breast cancer patients than in the controls at p < 0.05, while the serum level of NEAT1 was significantly lower in the breast cancer patients compared to the control group at p < 0.01 and no significant difference was observed in the serum level of MALATl in breast cancer patients. This evidence concerns the gene PVT1 and breast cancer.