CYP3A4 and cancer: Moreover, a combination of SJW extracts (9–19 mg of hyperforin and 0.36–0.84 mg of hypericin per 300 mg dried extract; Hyperiplant, VSM Geneesmiddelen BV, Alkmaar, Netherlands) and docetaxel (DCT), one of the anti-cancer drugs for brain tumors, can cause significant decrease in the AUC value of DCT and significant increase of its systemic clearance by upregulating the expression of CYP3A4 in the liver and P-gp in the intestine, hepato-biliary membrane, and BBB of cancer patients by SJW extracts [58].