Among down-regulated genes, the analysis showed several experimentally validated target genes, such as E2F7 [28], MAP2K1 (also known as MEK1) [29], CCNG1 [24], HMGB2 [30], SIRT1 [22], belonging to key signaling pathways frequently associated to melanoma (Supplementary Materials Table S1; Figure 5A). This evidence concerns the gene HMGB2 and melanoma.