KCC2 is predominantly expressed at inhibitory synapses in both the dorsal and ventral horn of the spinal cord [34] and an association between depletion of spinal KCC2 protein and loss of RDD has been found in animal models of spinal cord injury, STZ-induced diabetes, stroke, acute intrathecal administration of BDNF and genetic reduction of KCC2 protein expression [6,7,16,18]. This evidence concerns the gene BDNF and diabetes mellitus.