Potential scope of approved lysosomotropic drugs, RNA-dependent RNA polymerase (RdRp) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antivirals (remdesivir), and transmembrane serine protease 2 (TMPRSS2) inhibitors (nafamostat, camostat), in the prophylaxis and severity of SARS-CoV-2 infection/COVID-19. The gene discussed is TMPRSS2; the disease is COVID-19.