In 2020, immunotherapy re-shuffled the cards with the combination Atezolizumab (an anti-programmed death-ligand 1 (PDL-1) antibody) plus Bevacizumab (an anti-vascular endothelial growth factor (VEGF) antibody), considerably increasing tumor response and survival outcomes and becoming the new first line therapy of advanced HCC. This evidence concerns the gene VEGFA and hepatocellular carcinoma.