VEGFA and neoplasm: In 2020, immunotherapy re-shuffled the cards with the combination Atezolizumab (an anti-programmed death-ligand 1 (PDL-1) antibody) plus Bevacizumab (an anti-vascular endothelial growth factor (VEGF) antibody), considerably increasing tumor response and survival outcomes and becoming the new first line therapy of advanced HCC.