Since the cGAS-STING pathway plays a crucial role in oncogenesis, by sensing self DNA fragments derived from oxidative, infection, and other stresses, it is plausible that these TRIMs connect the cGAS-STING-mediated innate immunity and carcinogenesis via the autophagy machinery, which plays fundamental roles in antiviral and antitumor defense and is a potential target for cancer immunotherapy [233,234,235,236,237,238,239,240]. The gene discussed is STING1; the disease is cancer.