In addition, CPS1 expression in HCC tissue inversely correlated with proliferation rate (R = −0.27, p = 1.31 × 10−10), AFP serum levels (R = −0.23, p = 2 × 10−6), AFP immunoreactivity (R = −0.25, p = 4.5 × 10−9), cytokeratin 19 (CK19) immunoreactivity (R = -0.26, p = 2.64 × 10−9), and CAD expression (R = −0.16, p = 0.000316). The gene discussed is CAD; the disease is hepatocellular carcinoma.