Once expressed, this HERV clone 3’LTR restrains miR-302d activity (an inhibitory miRNA, abnormally downregulated in SLE monocytes), activating a cascade which leads to DNA hypomethylation, IL17 release from CD4+ T-cells and type I IFN response [146,147,148]. The gene discussed is IL17A; the disease is systemic lupus erythematosus.