Human Papillomavirus (HPV) is a dsDNA virus which has recently been proposed to play a role in SLE pathogenesis on the basis of several elements: HPV seroprevalence is increased among SLE patients, SLE development post-HPV vaccination has been reported and a large peptide overlap has emerged between HPV L1 proteins and many human proteins such as lupus Ku autoantigen proteins p86 and p70, lupus brain antigen 1 homolog and others. Here, TRANK1 is linked to systemic lupus erythematosus.