LMP-1 has more complex functions, highly relevant to autoimmunity: it induces BAFF (B-cell activating factor of the tumor necrosis family), which rescues self-reactive B cells, it can determine a SLE-like form in transgenic mice [77] and has been associated with type I IFN pathway activation in SLE [68]. This evidence concerns the gene TNFSF13B and Autoimmunity.