ONECUT2 and breast cancer: Moreover, chemotherapy has been found to stimulate breast cancer cells to secrete multiple vesicular miRNAs, including miR-203a-3p, miR-195-5p, and miR-9-5p, which simultaneously inactivate the transcription factor one cut homeobox 2 (ONECUT2) and increase the expression of stemness-associated genes, such as SOX2, OCT4, NANOG, SOX9, and NOTCH1; inhibition of these miRNAs or restoration of ONECUT2 expression abolishes the CSC-stimulating effect of EVs from chemotherapy-treated cancer cells [130].