Furthermore, stroma-derived EVs have been reported to induce dedifferentiation of lung and breast cancer cells to a chemoresistant CSC-like phenotype via neurogenic locus notch homolog protein 3 (Notch3)/signal transducer and activator of transcription 1 (STAT1) signaling and interleukin-6 (IL-6), activin-A, and granulocyte colony stimulating factor (G-CSF), respectively [132,133]. This evidence concerns the gene NOTCH3 and breast cancer.