EPCAM and neoplasm: Similar results have been obtained in OVCAR-5 ovarian carcinoma cells, where an enrichment in the drug-resistant EpCAM+CD45+ subpopulation has been observed after treatment with EVs secreted by the non-tumor cells of the ascitic fluid [134]; likewise, fibroblast-derived EVs stimulate growth and clonogenicity of colorectal CSCs (i.e., CD133+ and TOP-GFP+) upon treatment with oxaliplatin and 5-fluorouracil [135].