Regarding immune surveillance evasion, it should also be emphasized that tumor-secreted EVs can directly impair CD8+ T lymphocyte function by carrying the pro-apoptotic Fas Ligand (FasL) and the suppressive galectin-1 and -9, both in vitro and in vivo [115,116,117,118,119,120,121]. This evidence concerns the gene FASLG and neoplasm.