Among these, 225 participants were excluded because of type 2 diabetes, coronary heart disease, previous stroke or use of statins or other lipid-lowering drugs (including fibrates, ezetimibe, proprotein convertase subtilisin/kexin type 9 inhibitors, and omega-3 fatty acids) in different combinations, four cases were excluded because of incomplete data, and 2 cases were excluded because of pregnancy. The gene discussed is PCSK9; the disease is Stroke.