Recent results reinforced a central role for the NLRP3/caspase-8 inflammasome pathway in MS by showing that stimulation of PBMCs from primary progressive MS (PPMS) patients with Monosodium Urate Crystals (MSU) resulted in a significant increase in the expression of NLRP3 and ASC-speck protein and in IL-18 and caspase-8 production. Here, CASP8 is linked to primary progressive multiple sclerosis.