Interestingly, IL1β and IL-6 production was increased, whereas that of IL-10 was reduced in α-syn-stimulated cells of PD patients, suggesting that PD-associated neuroinflammation is not the consequence of the activation of the NLRP3 inflammasome but rather of an imbalance between pro- and anti-inflammatory cytokines. Here, IL10 is linked to Parkinson disease.