Binding to the transactivation domain of p53 (LargeT antigen of the SV40 virus), expression of anti-apoptotic proteins (LMP1 of Epstein-Barr virus) and promotion of p53 mutations (Hepatitis B virus) are also used by tumor viruses to inhibit p53 activity [204,205,206]. This evidence concerns the gene TP53 and neoplasm.