Stable overexpression of TRIM71 in ES-2 and OVCA420 cells reduced the expression of target genes of mutated p53 including c-Myc, MMP3 or RANGAP1 and suppressed cell proliferation, invasion and tumor growth in xenografts while it barely affected expression of wild-type p53 and proliferation or invasion of ovarian cancer cells with wild-type p53 [213]. The gene discussed is TP53; the disease is ovarian carcinoma.