Furthermore, this real-life study was conducted by qualified pulmonologists and immunologists who were actively involved in SAA management in a referral hospital setting and confirmed the diagnosis of SAA based on the GINA recommendations, elevated serum total IgE level and the presence of a history of allergic reaction, tested allergens and/or concomitant atopic diseases, ensuring a valid study population of patients with SAA although in-vivo skin prick test for determination of allergy had not been performed for the participants [1]. This evidence concerns the gene IGHE and Allergy.