Some food preservatives, considered as food antioxidants, including sodium sulfite, sodium benzoate, some spice compounds, and natural colorants (such as curcumin), diminish the liberation of leptin in murine 3T3-L1 adipocytes—in which obesity-like inflammation was induced which co-incubation with lipopolysaccharide (LPS). The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.