In addition, the local overexpression of ACE2 in cirrhosis [36] not only ameliorated liver fibrosis but also reduced hepatic perfusion pressure in experimental mouse models by decreasing the levels of vasoconstrictor peptide Ang II whilst simultaneously increasing the levels of vasodilator peptide Ang-(1–7) in the cirrhotic livers [36,64]. The gene discussed is ACE2; the disease is Hepatic fibrosis.