It is also shown that Ang-(1–7)/Ang II ratio is significantly elevated in the splanchnic compared to systemic circulations in the cirrhotic patients undergoing liver transplant, which is also negatively correlated with the systemic vascular resistance, suggesting that the augmented Ang-(1–7) activity contributes to the splanchnic vasodilatation in cirrhosis [115]. The gene discussed is ANG; the disease is Cirrhosis.