PBK and primary central nervous system lymphoma: Moreover, cytoplasmic PBK/TOPK was reported to be an independent prognostic marker for five-year survival of colorectal cancer patients, while higher expression of p-TOPK, but not TOPK, predicted poor prognosis, including significantly shorter progression-free survival (PFS) and overall survival (OS) in patients with primary central nervous system lymphoma [51,52].