SmFRET and FCS have been applied to study the conformations and dynamics of amyloidogenic proteins including the Alzheimer’s-related amyloid β-peptide (Aβ) [37] and Tau [38,39,40], the Parkinson’s-related protein α-synuclein [41,42,43,44,45,46], the amyotrophic lateral sclerosis-related protein TAR DNA-binding protein 43 (TDP-43) [47], Huntington’s disease-related huntingtin [48], and the yeast prion proteins Ure2 [49] and Sup35 [50]. This evidence concerns the gene TARDBP and glycogen storage disease VI.