Significant differences in surgical type (p < 0.001), tumor size (p < 0.001), lymph node status (p < 0.001), histologic grade (p = 0.011), ER intensity (p = 0.029), PgR status (p = 0.001), PgR intensity (p < 0.001), hormone therapy type (p < 0.001), and chemotherapy (p < 0.001) were observed between the two groups. The gene discussed is ESR1; the disease is neoplasm.