When these subjects were further stratified into five subgroups (lean controls with normal glucose tolerance; overweight/obese with normal glucose tolerance; overweight/obese with impaired glucose tolerance; T2D-autoantibody negative; T2D autoantibody positive), no statistical differences in unmethylated INS or CHTOP were observed across these cross-sectional cohorts. Here, CHTOP is linked to Impaired glucose tolerance.