CD19 and acute lymphoblastic leukemia: In another randomized phase 3 trial involving adults with Ph-negative R/R B-cell precursor ALL, blinatumomab (a bispecific monoclonal antibody construct that enables CD3-positive T cells to recognize and eliminate CD19-positive ALL blasts), resulted in significantly longer overall survival (OS) than standard chemotherapy, and the risk of death was 29% lower in the blinatumomab group than in the chemotherapy group (14).