In a study on myocardial ischemia patients’ blood and OGD-treated rat H9c2 cells, the expression of circDENND2A (hsa_circ_0002142), which was highly expressed in HIF-1α induced glioma cells, was both significantly elevated in myocardial ischemia patients and conspicuously enhanced under OGD treatment. The gene discussed is HIF1A; the disease is myocardial ischemia.