OXT and schizophrenia: Oxytocin knock-out mice exhibited enhanced deficits in the prepulse inhibition of the startle reflex [35], an endophenotype of schizophrenia that reflects an underlying abnormality in sensorimotor gating of excessive environmental stimuli [36], suggesting that endogenous oxytocin has a protective effect against hypofunction of the glutamatergic system in schizophrenia.