PON1 and coronary artery disorder: Opposite to this, in the meta-analyses conducted by Wheeler et al. and by Wang et al., who evaluated results of, respectively,43 and 88 case-control studies regarding genetic variations at positions -108, 55 and 192 of the PON1 gene and in position 311 of the PON2 gene as potential risk factors of CHD, the investigators found only a weak relationship between the occurrence of the 192R PON1 allele and CHD [95,96].