In the larger group of 730 Caucasian and 467 African American subjects with AD enrolled in the MIRAGE study, 29 SNPs in the PON1, PON2 and PON3 genes were analyzed, including 192 Q/R, 55 L/M in the coding region of PON1 and 311 C/S of PON2, 31 F/S of PON3, -107 C/T and -161 C/T in the promoter region of the PON1 gene as well as intronic and intragenic variations. The gene discussed is PON3; the disease is Alzheimer disease.